Dr. Tanusree Sengupta is an Assistant Professor in the Department of Chemistry, School of Science and Humanities, Shiv Nadar University Chennai. She received her Ph.D. in Biochemistry from Bose Institute, Jadavpur University, and completed postdoctoral research at Case Western Reserve University and the University of North Carolina at Chapel Hill, USA. Her research focuses structural and functional characterization of proteins involved in blood coagulation and haemostasis, peptide–membrane interactions, and computational biology. She has led and collaborated on several externally funded projects supported by the DBT, DST, SERB, and the Shiv Nadar Foundation. She is a recipient of the DBT-BioCARe Fellowship and the ISTH Reach the World Travel Grant.

Work Experience

Teaching:10 years, Research:7 years

• 1^st Aug 2016 -30^th June 2026, Assistant Professor, Dept. of Chemistry, SSN College of Engineering, 
• 2013-2016, DBT-BioCARe Fellow, Dept. of Biotechnology, IIT Madras
• 2009-2012, Postdoctoral Research Associate, Dept. of Biochemistry & Biophysics, UNC at Chapel Hill, USA, 
• 2008-2009, Postdoctoral fellow, Dept. of Physiology & Biophysics, Case Western Reserve University, USA, 

Projects

1. Ongoing

• “Structural and functional characterization of R372 and E375 variants of ZPI (Protein Z-dependent Protease Inhibitor)” funded by DST, Department of Science & Technology. Govt of India (2024 Mar-2027 Feb) in the DST-WOS category, Sanctioned amount: Rs 25.32 lakh.
• “Exploring Flexible UV LED for Disinfection of Secondary Treated Municipal Wastewater” Funded by Shiv Nadar Foundation (2024-2027), Sanctioned Amount: 36.73 Lakh jointly with Shiv Nadar University, Chennai.

2. Completed

• “Characterization of Novel Mutants of Human Protein Z-dependent Protease Inhibitor (ZPI): Potential Therapeutics for Hemophilia” funded by DST-SERB, Department of Science & Technology. Govt of India. (2022 Feb-2025 Feb) in the CRG (Core Research Grant) category. Sanctioned amount: Rs 60.46 lakh jointly with IIT Madras.
• “Role of PZ-ZPI anticoagulant system on COVID-19 associated coagulopathy”. Google Cloud Research credit was awarded for 365 days by Google Cloud Research credits Program for carrying out computational work on the above mentioned project (Jun 2021-June 2022).
• “Understanding the Structure Function Relationship of the Natural Anticoagulant ZPI, a Member of Serpin Superfamily”-funded by DST-SERB, Department of Science & Technology. Govt of India. (2018 Jun-2022 Jan) in the ECR (Early Career Research) category.  Sanctioned amount: 34.62 lakh.

Publications

1. Journal Publications

1. S Pradhan, T Sengupta, H Chakraborty. Phosphatidylserine Promotes Tighter Membrane Binding of Clusterin Signal Peptide over Phosphatidylglycerol, While Phosphatidylethanolamine Allows Its Deeper Penetration. The Journal of Physical Chemistry B 2025, 129 (47), 12159-12166.
2. C Suganthi, P Akshayaa, T Sengupta, N Manoj. Unveiling the Evolutionary History and Functional Significance of the Protein Z-Dependent Protease Inhibitor (ZPI) Across Vertebrates. Journal of Molecular Evolution 2025, 93 (5), 636-649.
3. S Pradhan, L Mirdha, T Sengupta, H Chakraborty. Implications of the Lipidic Ecosystem for the Membrane Binding of ApoE Signal Peptide: Importance of Sphingomyelin. ChemBioChem 2024, 25 (22), e202400469.
4. S Pradhan, L Mirdha, T Sengupta, H Chakraborty. Phosphatidylglycerol Acts as a Switch for Cholesterol-Dependent Membrane Binding of ApoE Signal Peptide.Langmuir 2024, 40 (15), 8126-8132.
5. T Sengupta, A Luiz, C Suganthi, S Majumder. Coagulopathy in severe COVID-19 patients: causes, concerns and current treatment regimen. Acta Haematologica Polonica 2023, 55 (1), 13-21.
6. L Mirdha, T Sengupta, H Chakraborty. Lipid composition dependent binding of apolipoprotein E signal peptide: Importance of membrane cholesterol in protein trafficking. Biophysical Chemistry 2023, 291, 106907.
7. Chellam Gayathri S, Gupta S, Suresh A, Senapati S, Sengupta T. Effect of variations in the conserved residues E371 and S359 on the structural dynamics of protein Z dependent protease inhibitor (ZPI): a molecular dynamic simulation study. J Biomol Struct Dyn 2022, 40(14), 6405–6414, doi.org/10.1080/07391102.2021.1883114.
8. Sengupta T, Majumder R, Majumder S. Role of vitamin D in treating COVID-19- associated coagulopathy: problems and perspectives. Mol Cell Biochem 2021, 476, 2421-2427. https://doi.org/10.1007/s11010-021-04093-6
9. Sengupta T, Koklic T, Lentz BR, Majumder R. Phosphatidylserine and phosphatidylethanolamine regulate the structure and function of FVIIa and its interaction with soluble tissue factor. Biosc Reports. 2021, 41 (2): BSR20204077. https://doi.org/10.1042/BSR20204077
10. Chatterjee S, Sengupta T, Majumder S, Majumder R. COVID 19: A Probable Role of the Anticoagulant Protein S in Managing COVID-19-Associated Aging. 2020, 12, 15954-61. 
11. Sengupta T, Manoj N. Phosphatidylserine and Phosphatidylethanolamine Bind to Protein Z cooperatively and with Equal Affinity. PLoS One. 2016, 11(9), e0161896.
12. Chakraborty H, Sengupta T, Lentz BR. pH Alters PEG-mediated Fusion of Phosphatidyl ethanolamine-Containing Vesicles. Biophys J. 2014, 107(6), 1327-38. 
13. Sengupta T, Chakraborty H, Barry R. Lentz.The Transmembrane Domain Peptide of Vesicular Stomatitis Virus Promotes Both Intermediate and Pore Formation during PEG-mediated Vesicle Fusion. Biophys J. 2014, 107(6), 1318-26. 
14. Majumder R, Koklic T, Sengupta T, Cole D, ChattopadhyayR, Biswas S, Monroe D and Barry R. Lentz. Soluble Phosphatidylserine Binds to Two Sites on Human Factor IXa in a Ca2+ Dependent Fashion toSpecifically Regulate Structure and Activity. PLoS One.2014, 9(6). 
15. Chattopadhyay R, Sengupta T, Majumder R. Inhibition of Intrinsic Xase by Protein S – a novel regulatory role of Protein S independent of Activated Protein C. Arteriosclerosis, Thrombosis and Vascular biology. 2012, 32(10), 2387-93. Chosen as a Cover page of that issue of the journal. 
16. Chakraborty H, Tarafdar PK, Bruno MJ, Sengupta T, Lentz BR. Activation thermodynamics of poly (ethylene glycol)-mediated model membrane fusion Support mechanistic model of stalk and pore formation. Biophys J. 2012, 102(12), 2751-60. 
17. Sengupta T, Tsutsui Y, Wintrode PL. Local and Global Effects of a Cavity Filling Mutation in a Metastable Serpin. 2009, 48, 8233-8240. 
18. Tsutsui Y, Kuri B, Sengupta T, Wintrode PL. The structural basis of serpin polymerization studied by hydrogen/ deuterium exchange and mass spectrometry. J Biol Chem. 2008, 283, 30804-11. 
19. Sengupta T, Ghoshal S, Dungdung SR, Majumder GC, Sen PC. Structural and functional characterization and physiological significance of a stimulator protein of Mg²⁺-independent Ca²⁺-ATPase isolated from goat spermatozoa. Mol Cell Biochem. 2008, 311, 93-103.
20. Sengupta T, Ghoshal S, Sen PC. Stimulation of Mg²⁺– independent form of Ca²⁺-ATPase by a low molecular mass protein purified from goat testes cytosol. Biochem. Physiol. B. 2007, 146, 131-138. 
21. Ghoshal S, Sengupta T, Dundung SR, Majumder GC, Sen PC. Characterization of a low-molecular-mass stimulator protein of Mg²⁺ independent Ca²⁺-ATPase: effect on phosphorylation/dephosphorylation, calcium transport and sperm-cell motility. Biosci Rep. 2008, 28, 61-71. 
22. Ghoshal S, Sengupta T, Sen PC. Regulation of Mg²⁺-independent Ca²⁺-ATPase by a low molecular mass protein purified from bovine brain. Biofactors 2006, 26(4), 259–271

2. Papers presented in International Conference

1. Suganthi C, Sengupta T , Manoj N. Detailed phylogenetic analyses of Serpina10 Indicated Diverse Physiological roles of Protein Z Dependent Protease Inhibitor (ZPI), Res Pract Thromb Haemost.2024, (Page no 402, article 102504) Presented in the ISTH 2024 congress held in Bangkok, Thailand during 22^nd-26^th June 2024.
2. Sengupta T, Suganthi C, Manoj N. Probable Interaction of Protein Z Dependent Protease Inhibitor with Plasma Pre-kallikrein as Revealed by Phylogenetic Analyses, Res Pract Thromb Haemost.2024, (Page no 400, article 102504) Presented in the ISTH 2024 congress held in Bangkok, Thailand during 22^nd-26^th June 2024.
3. Sengupta T, Gayathri S, Gupta S. Ca²⁺ and Zn²⁺ binding to human Protein Z (PZ) induces structural changes that augments its lipid binding, Research and Practice in Thrombosis and Haemostasis: Volume 6, Issue S1 (e12789), Presented in the ISTH 2022 congress held in London, UK during 9^th -13^th July 2022.
4. Sengupta T, Subash CG, Gupta S. Identification of Key Residues in Protein Z Dependent Protease Inhibitor (ZPI) for Efficient Protease Inhibiton [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). Presented in the ISTH 2020 Virtual congress, 12-14th July, 2020.
5. Sengupta T, Plautz W, Subhash CG, Manoj N, Majumder R. Zinc Binds and Regulates the Activity of the Natural Anticoagulant Protein Z [abstract]. Res Pract Thromb Haemost. 2017; 1 (suppl 1).
6. Sengupta T, Manoj N. Similar responses of phosphatidylserine and phosphatidylethanolamine towards cofactor activity of human protein Z, a natural anticoagulant. Journal Of Thrombosis and Haemostasis 13, 631-632, Presented in the ISTH 2015 congress held in Toronto, Canada, 2015.

3. Professional Recognition

1. Recipient of ‘Reach the World’ travel grant to present paper in ISTH (International Society on Thrombosis & Haemostasis) meeting in 2022, 2017, and 2015 held in London, Berlin, and Toronto respectively.
2. DBT-BioCARe Fellowship by Department of Biotechnology, Govt. of India
3. CSIR-NET Fellowship, 2001 December.

Membership in Professional Bodies

• Reach the World member of International Society on Thrombosis & Haemostasis (ISTH).
• Life member of Society of Materials Chemists (SMC India)

Area of Research

• Structural and functional characterization of proteins involved in Blood coagulation and Haemostasis
• Peptide-lipid interaction
• Computational biology
• Functional Biomaterials

Links

• https://scholar.google.com/citations?user=UCZ7uokAAAAJ&hl=en
• https://www.scopus.com/pages/authors/15066044800
• https://orcid.org/0000-0002-6828-667X
• https://sites.google.com/view/tanusree-sengupta-ssn